| http://purl.uniprot.org/citations/30236141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30236141 | http://www.w3.org/2000/01/rdf-schema#comment | "Oncogenic fusion gene Echinoderm Microtubule-associated protein-Like 4-Anaplastic Lymphoma Kinase (EML4-ALK) contributes to tumorigenesis of a subset of non-small cell lung cancer (NSCLC). Recently, we demonstrated that F-circEA-4a, a tumor-promoting circular RNA (circRNA) generated from the back-splicing of EML4-ALK variant 3b (v3b), is a novel liquid biopsy biomarker for NSCLC. However, circRNAs produced from EML4-ALK gene and their roles in NSCLC are not well-characterized. Here, we identify another EML4-ALK-v3b-derived circRNA, F-circEA-2a, harboring "AA" (rather than "AAAA" in F-circEA-4a) motif at the junction site. F-circEA-2a mainly locates in the cytoplasm and promotes cell migration and invasion, but has little effect on cell proliferation. Moreover, F-circEA-2a exists in tumor, but not in the plasma of NSCLC patients with EML4-ALK fusion gene, further supporting the significant diagnostic value of F-circEA-4a for EML4-ALK-positive NSCLC. This work finds a novel oncogenic circRNA generated from EML4-ALK fusion gene, highlighting the pivotal role of circRNA in EML4-ALK-positive NSCLC development."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12943-018-0887-9"xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Gong Y."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Guo C."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Sun D."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Peng Y."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Tan S."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Pu W."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Wei Y.Q."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/author | "Gou Q."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/name | "Mol Cancer"xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/pages | "138"xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/title | "Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/30236141 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30236141 |
| http://purl.uniprot.org/citations/30236141 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30236141 |
| http://purl.uniprot.org/uniprot/#_A0A0K2YUJ3-mappedCitation-30236141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30236141 |
| http://purl.uniprot.org/uniprot/#_D1MAM4-mappedCitation-30236141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30236141 |
| http://purl.uniprot.org/uniprot/#_D1MAM5-mappedCitation-30236141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30236141 |
| http://purl.uniprot.org/uniprot/#_B4DIT9-mappedCitation-30236141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30236141 |