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| http://purl.uniprot.org/citations/30243515 | http://www.w3.org/2000/01/rdf-schema#comment | "Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a major player in preserving tissue integrity and has recently also emerged as a decisive factor in several human pathologies. This appreciation has prompted this review addressing the largely underestimated complexity of the functions executed by TIMP-1 and their mechanistic basis. In fact, the versatile impact of TIMP-1 on cellular functions stems from its two-domain structure harboring metalloproteinase-inhibitory and cytokine-like signaling activities. This feature leads to functional interactions with numerous and distinct enzymatic and cell-surface proteins that initiate an exceptionally broad range of downstream effects. We propose here that this multifunctionality and the remarkably large interactome explain the diverse biological consequences of TIMP-1 expression in health and disease."xsd:string |
| http://purl.uniprot.org/citations/30243515 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.tcb.2018.08.006"xsd:string |
| http://purl.uniprot.org/citations/30243515 | http://purl.uniprot.org/core/author | "Kruger A."xsd:string |
| http://purl.uniprot.org/citations/30243515 | http://purl.uniprot.org/core/author | "Grunwald B."xsd:string |
| http://purl.uniprot.org/citations/30243515 | http://purl.uniprot.org/core/author | "Schoeps B."xsd:string |
| http://purl.uniprot.org/citations/30243515 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30243515 | http://purl.uniprot.org/core/name | "Trends Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/30243515 | http://purl.uniprot.org/core/pages | "6-19"xsd:string |
| http://purl.uniprot.org/citations/30243515 | http://purl.uniprot.org/core/title | "Recognizing the Molecular Multifunctionality and Interactome of TIMP-1."xsd:string |
| http://purl.uniprot.org/citations/30243515 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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