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Background

Human leukocyte antigen (HLA) complex is a gene family involved in antigen presentation associated with protection or susceptibility to inflammatory, infectious and autoimmune diseases. Atherosclerosis is a chronic inflammatory disease in which HLA molecules play a role in the initiation and development of the disease through presentation of self or foreign antigens to T cells.

Objective

To investigate the association of HLA-DRB1 alleles with atherosclerosis in a sample of southwestern Iranians.

Methods

We performed an analytical cross-sectional study involving 96 patients with atherosclerosis and 72 controls. HLA-DRB1 genotyping was performed by PCR-SSP method.

Results

We observed a significantly lower frequency of DRB1*01 in patients with coronary artery atherosclerosis than in controls (4.68% vs. 13.1, P=0.0052, OR=3.09, CI 95%: 1.35-7.05). However, this allele showed a positive association with high blood pressure (P=0.009) in patients. Furthermore, DRB1*16 allele was associated with hyperlipidemia (P=0.008) in patients.

Conclusion

Our results demonstrated that DRB1*01 may be a protective allele against atherosclerosis in individuals who live in southwest of Iran. The mechanism of this protection needs further investigation."xsd:string
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http://purl.uniprot.org/citations/30246695http://purl.uniprot.org/core/author"Farjadian S."xsd:string
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http://purl.uniprot.org/citations/30246695http://purl.uniprot.org/core/pages"197-206"xsd:string
http://purl.uniprot.org/citations/30246695http://purl.uniprot.org/core/title"Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis."xsd:string
http://purl.uniprot.org/citations/30246695http://purl.uniprot.org/core/volume"15"xsd:string
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