| http://purl.uniprot.org/citations/30258449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30258449 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy has been implicated in innate immune responses against various intracellular pathogens. Recent studies have reported that autophagy can be triggered by pathogen recognizing sensors, including Toll-like receptors and cyclic guanosine monophosphate-adenosine monophosphate synthase, to participate in innate immunity. In the present study, we examined whether the RIG-I signaling pathway, which detects viral infections by recognizing viral RNA, triggers the autophagic process. The introduction of polyI:C into the cytoplasm, or Sendai virus infection, significantly induced autophagy in normal cells but not in RIG-I-deficient cells. PolyI:C transfection or Sendai virus infection induced autophagy in the cells lacking type-I interferon signaling. This demonstrated that the effect was not due to interferon signaling. RIG-I-mediated autophagy diminished by the deficiency of mitochondrial antiviral signaling protein (MAVS) or tumor necrosis factor receptor-associated factor (TRAF)6, showing that the RIG-I-MAVS-TRAF6 signaling axis was critical for RIG-I-mediated autophagy. We also found that Beclin-1 was translocated to the mitochondria, and it interacted with TRAF6 upon RIG-I activation. Furthermore, Beclin-1 underwent K63-polyubiquitination upon RIG-I activation, and the ubiquitination decreased in TRAF6-deficient cells. This suggests that the RIG-I-MAVS-TRAF6 axis induced K63-linked polyubiquitination of Beclin-1, which has been implicated in triggering autophagy. As deficient autophagy increases the type-I interferon response, the induction of autophagy by the RIG-I pathway might also contribute to preventing an excessive interferon response as a negative-feedback mechanism."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2018.02096"xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Choi J.Y."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Jung J.U."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Lee J.K."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Inn K.S."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Cho N.H."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Ban J."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Lee N.J."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Lee N.R."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Seong J."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/author | "Yi C.M."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/pages | "2096"xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/title | "Activation of RIG-I-Mediated Antiviral Signaling Triggers Autophagy Through the MAVS-TRAF6-Beclin-1 Signaling Axis."xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30258449 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30258449 |
| http://purl.uniprot.org/citations/30258449 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30258449 |
| http://purl.uniprot.org/uniprot/#_A0A024R1X5-mappedCitation-30258449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30258449 |
| http://purl.uniprot.org/uniprot/#_B3KN51-mappedCitation-30258449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30258449 |
| http://purl.uniprot.org/uniprot/#_B4DQ36-mappedCitation-30258449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30258449 |
| http://purl.uniprot.org/uniprot/#_B4DWT9-mappedCitation-30258449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30258449 |