| http://purl.uniprot.org/citations/30266591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30266591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30266591 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we investigated the gene of a transforming growth factor (TGF)-β type I receptor-like molecule in Haemonchus contortus, a highly pathogenic and economically important parasitic nematode of small ruminants. Designated Hc-tgfbr1, this gene is transcribed in all developmental stages of H. contortus, and the encoded protein has glycine-serine rich and kinase domains characteristic of a TGF-β family type I receptor. Expression of a GFP reporter driven by the putative Hc-tgfbr1 promoter localised to two intestinal rings, the anterior-most intestinal ring (int ring I) and the posterior-most intestinal ring (int ring IX) in Caenorhabditis elegans in vivo. Heterologous genetic complementation using a plasmid construct containing Hc-tgfbr1 genomic DNA failed to rescue the function of Ce-daf-1 (a known TGF-β type I receptor gene) in a daf-1-deficient mutant strain of C. elegans. In addition, a TGF-β type I receptor inhibitor, galunisertib, and double-stranded RNA interference (RNAi) were employed to assess the function of Hc-tgfbr1 in the transition from exsheathed L3 (xL3) to the L4 of H. contortus in vitro, revealing that both galunisertib and Hc-tgfbr1-specific double-stranded RNA could retard L4 development. Taken together, these results provide evidence that Hc-tgfbr1 is involved in developmental processes in H. contortus in the transition from the free-living to the parasitic stage."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ijpara.2018.06.005"xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ijpara.2018.06.005"xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Fang R."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Fang R."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "He L."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "He L."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Di W."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Di W."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Gasser R.B."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Gasser R.B."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Korhonen P.K."xsd:string |
| http://purl.uniprot.org/citations/30266591 | http://purl.uniprot.org/core/author | "Korhonen P.K."xsd:string |