| http://purl.uniprot.org/citations/30268501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30268501 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-11 belongs to the members of the IL-6 family of cytokines and is involved in a variety of biological responses, including hematopoiesis, bone development, and carcinogenesis. However, the cellular sources of IL-11 and regulation of IL-11 expression under physiological and pathological conditions are not fully understood. One of the causes to prevent characterization of IL-11 in vivo is due to the lack of reliable antibodies that detect IL-11 by immunohistochemistry. Moreover, although mice lacking Il11ra have been generated and extensively characterized, Il11-deficient mice have not been characterized yet. Here we generated two anti-IL-11 antibodies that blocked biological activities of IL-11 and detected IL-11 by immunohistochemistry, respectively. One clone of anti-IL-11 antibodies blocked IL-11-, but not IL-6-induced cell proliferation and IL-11-induced phosphorylation of STAT3 of an IL-11-dependent cell line. Moreover, we used recently established Il11-deficient mice to test the specificity of anti-IL-11 antibodies for immunohistochemistry. Another clone of anti-IL-11 antibodies stained stromal cells surrounding tumors of the colon of wild-type, but not Il11-deficient mice following treatment with Azoxymethane plus dextran sulfate sodium. Together, these newly developed anti-IL-11 antibodies provide a better understanding of the functions of IL-11 in vivo under various physiological and pathological conditions."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.09.128"xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Asano K."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Araki K."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Nakagawa Y."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Mikami T."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Nakano H."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Sakuma T."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Nakagata N."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Deguchi Y."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Nishina T."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/author | "Ohmuraya M."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/pages | "453-459"xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/title | "Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://purl.uniprot.org/core/volume | "505"xsd:string |
| http://purl.uniprot.org/citations/30268501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30268501 |
| http://purl.uniprot.org/citations/30268501 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30268501 |
| http://purl.uniprot.org/uniprot/#_A3KPB8-mappedCitation-30268501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30268501 |
| http://purl.uniprot.org/uniprot/#_F7A7F2-mappedCitation-30268501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30268501 |
| http://purl.uniprot.org/uniprot/#_Q3V0U3-mappedCitation-30268501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30268501 |