| http://purl.uniprot.org/citations/30277083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30277083 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased Hb A2 is considered the most reliable hematological finding for the identification of β-thalassemia (β-thal) carriers. The aim of this study was to determine the underlying genetic factors associated with a high Hb A2 level in a Chinese population. Subjects were recruited from couples preparing for pregnancy who participated in the thalassemia screening program during a 2-year period. DNA analyses were used for diagnosis of β-thal and other genetic factors. A total of 5985 adults who screened positive for β-thal were recruited. Of these, 5933 (99.1%) were detected to have a β-thal mutation. In the remaining 52 (0.9%) individuals without mutations involving the β-globin gene cluster, 16 were found to have Krüppel-like factor 1 (KLF1) gene variants, and two had an α-globin gene triplication. There were still 34 individuals with unknown genetic factors for their raised Hb A2 values. The results of this study indicate that genetic factors other than β-thal can rarely contribute to the elevation of Hb A2. These subjects usually have borderline microcytic red cell indices and Hb A2 values."xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.org/dc/terms/identifier | "doi:10.1080/03630269.2018.1509869"xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/author | "Jiang F."xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/author | "Zhou J.Y."xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/author | "Liao C."xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/author | "Chen G.L."xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/author | "Li D.Z."xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/name | "Hemoglobin"xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/pages | "154-158"xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/title | "Analysis of the Genotypes in a Chinese Population with Increased Hb A2 and Low Hematological Indices."xsd:string |
| http://purl.uniprot.org/citations/30277083 | http://purl.uniprot.org/core/volume | "42"xsd:string |
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