| http://purl.uniprot.org/citations/30282983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30282983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30282983 | http://www.w3.org/2000/01/rdf-schema#comment | "Scorpion sting envenoming impacts millions of people worldwide, with cardiac effects being one of the main causes of death on victims. Here we describe the first Ca2+ channel toxin present in Tityus serrulatus (Ts) venom, a cell penetrating peptide (CPP) named CPP-Ts. We show that CPP-Ts increases intracellular Ca2+ release through the activation of nuclear InsP3R of cardiomyocytes, thereby causing an increase in the contraction frequency of these cells. Besides proposing a novel subfamily of Ca2+ active toxins, we investigated its potential use as a drug delivery system targeting cancer cell nucleus using CPP-Ts's nuclear-targeting property. To this end, we prepared a synthetic CPP-Ts sub peptide14-39 lacking pharmacological activity which was directed to the nucleus of specific cancer cell lines. This research identifies a novel subfamily of Ca2+ active toxins and provides new insights into biotechnological applications of animal venoms."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-33133-3"xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-33133-3"xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Chavez-Olortegui C."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Chavez-Olortegui C."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Kalapothakis E."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Kalapothakis E."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Aguiar C.J."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Aguiar C.J."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Biscoto G.L."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Biscoto G.L."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Brandao-Dias P.F.P."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Brandao-Dias P.F.P."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Cardoso V.N."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Cardoso V.N."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Horta C.C.R."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Horta C.C.R."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Leal H.G."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Leal H.G."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Leite M.F."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Leite M.F."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Miranda S.E.M."xsd:string |
| http://purl.uniprot.org/citations/30282983 | http://purl.uniprot.org/core/author | "Miranda S.E.M."xsd:string |