| http://purl.uniprot.org/citations/30285101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30285101 | http://www.w3.org/2000/01/rdf-schema#comment | "Actin filaments are widely involved in multiple cellular processes in oocyte meiosis, such as spindle migration and polar body extrusion. The actin nucleators like Arp2/3 complex and formins are the most recognized molecules for actin assembly in oocytes. In the present study, we report that the vesicle trafficking factor, RAB8A GTPase, is a new regulator critical for actin assembly in meiosis. Our results showed that RAB8A was localized at both the spindle periphery and cortex in mouse oocytes, which was similar to the localization patterns of actin filaments. RAB8A depletion caused spindle migration defects and the failure of polar body extrusion, which could have been due to decreases in both cytoplasmic and cortical actin filaments in oocytes. Based on mass spectrometry analysis, we showed that RAB8A promoted actin assembly through its modulation on the ROCK-LIMK signaling pathway. Moreover, we demonstrated that RAB8A colocalized and interacted with GM130 at the spindle periphery and that RAB8A depletion caused the disruption of GM130-docked Golgi distribution. Taken together, our data indicated that RAB8A was required for Golgi distribution, spindle migration, and polar body extrusion via ROCK-mediated actin assembly in mouse oocyte meiosis."xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.org/dc/terms/identifier | "doi:10.1093/biolre/ioy217"xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/author | "Wan X."xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/author | "Tang F."xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/author | "Pan M.H."xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/author | "Sun S.C."xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/author | "Lan M."xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/author | "Pan Z.N."xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/name | "Biol Reprod"xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/pages | "711-720"xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/title | "RAB8A GTPase regulates spindle migration and Golgi apparatus distribution via ROCK-mediated actin assembly in mouse oocyte meiosis†."xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/30285101 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30285101 |
| http://purl.uniprot.org/citations/30285101 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30285101 |
| http://purl.uniprot.org/uniprot/#_Q0PD50-mappedCitation-30285101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30285101 |
| http://purl.uniprot.org/uniprot/#_Q3UHW5-mappedCitation-30285101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30285101 |
| http://purl.uniprot.org/uniprot/#_P55258-mappedCitation-30285101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30285101 |
| http://purl.uniprot.org/uniprot/P55258 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30285101 |
| http://purl.uniprot.org/uniprot/Q3UHW5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30285101 |
| http://purl.uniprot.org/uniprot/Q0PD50 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30285101 |