| http://purl.uniprot.org/citations/30287284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30287284 | http://www.w3.org/2000/01/rdf-schema#comment | "Integrin-interacting protein Kindlin-2, as a focal adhesion protein, promotes growth and progression of breast cancer. However, the precise mechanism that underlie the role of Kindlin-2 in breast cancer is elusive. Here, we report that the expression of Kindlin-2 positively correlated with DNA methyltransferase 1(DNMT1) in breast cancer patients. Further, we found that DNMT1 was upregulated in mammary gland tissues of mammary specific Kindlin-2 transgenic mice. More importantly, high expression of DNMT1 was observed in mammary tumors formed by Kindlin-2 transgenic mice. On the basis of these observations, DNMT inhibitor 5-aza-CdR was used and found its treatment strongly decreased Kindlin-2-induced breast cancer cell proliferation and migration. Mechanistically, Kindlin-2 increased the stability of DNA methyltransferase DNMT1 through interaction with DNMT1 and methylated CpG islands in the E-cadherin promoter. Kindlin-2 increased the occupancy of DNMT1 at E-cadherin promoter, thereby suppressing E-cadherin expression. Taken together, our data reveal that Kindlin-2 promotes breast cancer development by enhancing the stability of DNMT1."xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2018.09.022"xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/author | "Qi L."xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/author | "Chu W."xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/name | "Int J Biochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/pages | "41-51"xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/title | "Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development."xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/30287284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30287284 |
| http://purl.uniprot.org/citations/30287284 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30287284 |
| http://purl.uniprot.org/uniprot/#_A8K6S3-mappedCitation-30287284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30287284 |
| http://purl.uniprot.org/uniprot/#_Q96AC1-mappedCitation-30287284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30287284 |
| http://purl.uniprot.org/uniprot/A8K6S3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30287284 |
| http://purl.uniprot.org/uniprot/Q96AC1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30287284 |