| http://purl.uniprot.org/citations/30287865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30287865 | http://www.w3.org/2000/01/rdf-schema#comment | "Intra-individual response time variability (IIRTV) is proposed as a viable endophenotype for many psychiatric disorders, particularly attention-deficit hyperactivity disorder (ADHD). Here we assessed whether IIRTV was associated with common DNA variation genome-wide and whether IIRTV mediated the relationship between any associated loci and self-reported ADHD symptoms. A final data set from 857 Australian young adults (489 females and 368 males; Mage = 22.14 years, SDage = 4.82 years) who completed five response time tasks and self-reported symptoms of ADHD using the Conners' Adult ADHD Rating Scale was used. Principal components analysis (PCA) on these response time measures (standard deviation of reaction times and the intra-individual coefficient of variation) produced two variability factors (labelled response selection and selective attention). To understand the genetic drivers of IIRTV we performed a genome-wide association analysis (GWAS) on these PCA-derived indices of IIRTV. For the selective attention variability factor, we identified one single-nucleotide polymorphism (SNP) attaining genome-wide significance; rs62182100 in the HDAC4 gene located on chromosome 2q37. A bootstrapping mediation analysis demonstrated that the selective attention variability factor mediated the relationship between rs62182100 and self-reported ADHD symptoms. Our findings provide the first evidence of a genome-wide significant SNP association with IIRTV and support the potential utility of IIRTV as a valid endophenotype for ADHD symptoms. However, limitations of this study suggest that these observations should be interpreted with caution until replication samples become available."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41398-018-0262-z"xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Klein M."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Tong J."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Johnson B."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Hawi Z."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Franke B."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Pinar A."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Cummins T."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Bellgrove M.A."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Fornito A."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Pauper M."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Finlay A."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/author | "Tiego J."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/name | "Transl Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/pages | "207"xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/title | "Genome-wide association study reveals novel genetic locus associated with intra-individual variability in response time."xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/30287865 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30287865 |
| http://purl.uniprot.org/citations/30287865 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30287865 |
| http://purl.uniprot.org/uniprot/#_P56524-mappedCitation-30287865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30287865 |
| http://purl.uniprot.org/uniprot/#_A0A7I2SVS4-mappedCitation-30287865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30287865 |
| http://purl.uniprot.org/uniprot/#_B7Z8G5-mappedCitation-30287865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30287865 |