| http://purl.uniprot.org/citations/30295127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30295127 | http://www.w3.org/2000/01/rdf-schema#comment | "A key step in pre-mRNA splicing is the recognition of 3' splicing sites by the U2AF large and small subunits, a process regulated by numerous trans-acting splicing factors. How these trans-acting factors interact with U2AF in vivo is unclear. From a screen for suppressors of the temperature-sensitive (ts) lethality of the C. elegans U2AF large subunit gene uaf-1(n4588) mutants, we identified mutations in the RNA binding motif gene rbm-5, a homolog of the tumor suppressor gene RBM5. rbm-5 mutations can suppress uaf-1(n4588) ts-lethality by loss of function and neuronal expression of rbm-5 was sufficient to rescue the suppression. Transcriptome analyses indicate that uaf-1(n4588) affected the expression of numerous genes and rbm-5 mutations can partially reverse the abnormal gene expression to levels similar to that of wild type. Though rbm-5 mutations did not obviously affect alternative splicing per se, they can suppress or enhance, in a gene-specific manner, the altered splicing of genes in uaf-1(n4588) mutants. Specifically, the recognition of a weak 3' splice site was more susceptible to the effect of rbm-5. Our findings provide novel in vivo evidence that RBM-5 can modulate UAF-1-dependent RNA splicing and suggest that RBM5 might interact with U2AF large subunit to affect tumor formation."xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.org/dc/terms/identifier | "doi:10.1080/15476286.2018.1526540"xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/author | "Hu S."xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/author | "Gao X."xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/author | "Zhou C."xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/author | "Gan W."xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/author | "Ma Y.C."xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/name | "RNA Biol"xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/pages | "1295-1308"xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/title | "RBM-5 modulates U2AF large subunit-dependent alternative splicing in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/30295127 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30295127 |
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