| http://purl.uniprot.org/citations/30300142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30300142 | http://www.w3.org/2000/01/rdf-schema#comment | "Activating mutations in the Wnt pathway drive a variety of cancers, but the specific targets and pathways activated by Wnt ligands are not fully understood. To bridge this knowledge gap, we performed a comprehensive time-course analysis of Wnt-dependent signaling pathways in an orthotopic model of Wnt-addicted pancreatic cancer, using a porcupine (PORCN) inhibitor currently in clinical trials, and validated key results in additional Wnt-addicted models. The temporal analysis of the drug-perturbed transcriptome demonstrated direct and indirect regulation of more than 3,500 Wnt-activated genes (23% of the transcriptome). Regulation was both via Wnt/β-catenin and through the modulation of protein abundance of important transcription factors, including MYC, via Wnt-dependent stabilization of proteins (Wnt/STOP). Our study identifies a central role of Wnt/β-catenin and Wnt/STOP signaling in controlling ribosome biogenesis, a key driver of cancer proliferation."xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci122383"xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/author | "Virshup D.M."xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/author | "Harmston N."xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/author | "Montoya A."xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/author | "Faull P."xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/author | "Madan B."xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/author | "Petretto E."xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/author | "Nallan G."xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/pages | "5620-5633"xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/title | "Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis."xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/30300142 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30300142 |
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