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| http://purl.uniprot.org/citations/30305326 | http://www.w3.org/2000/01/rdf-schema#comment | "Zika virus (ZIKV) outbreaks pose a massive public health threat in several countries. We have developed an in vivo model to investigate the host-ZIKV interaction in Drosophila We have found that a strain of ZIKV replicates in wild-type flies without reducing their survival ability. We have shown that ZIKV infection triggers RNA interference and that mutating Dicer-2 results in enhanced ZIKV load and increased susceptibility to ZIKV infection. Using a flavivirus-specific Ab, we have found that ZIKV is localized in the gut and fat body cells of the infected wild-type flies and results in their perturbed homeostasis. In addition, Dicer-2 mutants display severely reduced insulin activity, which could contribute toward the increased mortality of these flies. Our work establishes the suitability of Drosophila as the model system to study host-ZIKV dynamics, which is expected to greatly advance our understanding of the molecular and physiological processes that determine the outcome of this disease."xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1800597"xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/author | "Eleftherianos I."xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/author | "Nixon D.F."xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/author | "Paquin-Proulx D."xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/author | "Kitchen S.M."xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/author | "Harsh S."xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/author | "Ozakman Y."xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/pages | "3058-3072"xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/title | "Dicer-2 Regulates Resistance and Maintains Homeostasis against Zika Virus Infection in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/30305326 | http://purl.uniprot.org/core/volume | "201"xsd:string |
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