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http://purl.uniprot.org/citations/30308196http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30308196http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

The repression of renal Farnesoid X Receptor (FXR) had been shown to result from lack of bile acid production from cirrhotic liver. We hypothesized that silymarin and rosuvastatin (Rvs) could have a hepatorenal therapeutic effects in hepatic nephropathy through induction of FXR.

Methods

Forty two male Wistar rats were used; naïve (n = 12); six of them were sacrificed after 4 weeks and six continued till the end of the experiment. Thirty rats were treated as follows: Rvs, silymarin, thioacetamide (TAA), TAA + Rvs and TAA + silymarin. Liver and kidney function tests as well as the renal and hepatic expression of transforming growth factor β1 (TGFβ1), FXR, dimethylarginine dimethylaminohydrolase-1 (DDAH-1) and eNOS were performed. Histological and immuno-histochemical studies of liver and kidney were also done.

Results

TAA-inducted liver cirrhosis was associated with significant deterioration of liver and renal functions together with increasing expression of hepatic and renal TGFβ1 and decreasing expression of hepatic and renal FXR, DDAH-1 and eNOS. Giving silymarin or Rvs induced hepatic and renal improvement which was evidenced biochemically and histologically. Significant positive correlation was detected between all the investigated biomarkers except for the correlation between FXR and TGFβ1 which was negative.

Conclusions

In conclusion, liver cirrhosis is associated with deterioration of renal functions. Silymarin and Rvs have a potential hepatorenal therapeutic benefit through simultaneous enhancement of FXR/DDAH-1/eNOS pathway in both organs."xsd:string
http://purl.uniprot.org/citations/30308196http://purl.org/dc/terms/identifier"doi:10.1016/j.yexmp.2018.10.004"xsd:string
http://purl.uniprot.org/citations/30308196http://purl.uniprot.org/core/author"Nabih E.S."xsd:string
http://purl.uniprot.org/citations/30308196http://purl.uniprot.org/core/author"El-Kharashi O.A."xsd:string
http://purl.uniprot.org/citations/30308196http://purl.uniprot.org/core/author"Magdy Y.M."xsd:string
http://purl.uniprot.org/citations/30308196http://purl.uniprot.org/core/author"Abd El Samad A.A."xsd:string
http://purl.uniprot.org/citations/30308196http://purl.uniprot.org/core/author"El-Waseef D.A.A."xsd:string
http://purl.uniprot.org/citations/30308196http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/30308196http://purl.uniprot.org/core/name"Exp Mol Pathol"xsd:string
http://purl.uniprot.org/citations/30308196http://purl.uniprot.org/core/pages"293-310"xsd:string
http://purl.uniprot.org/citations/30308196http://purl.uniprot.org/core/title"Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy."xsd:string
http://purl.uniprot.org/citations/30308196http://purl.uniprot.org/core/volume"105"xsd:string
http://purl.uniprot.org/citations/30308196http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/30308196
http://purl.uniprot.org/citations/30308196http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/30308196
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http://purl.uniprot.org/uniprot/#_Q62735-mappedCitation-30308196http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30308196
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http://purl.uniprot.org/uniprot/A0A8L2Q4E9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/30308196
http://purl.uniprot.org/uniprot/Q62735http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/30308196
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