| http://purl.uniprot.org/citations/30312695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30312695 | http://www.w3.org/2000/01/rdf-schema#comment | "Amount of evidence demonstrate that aberrant microRNAs (miRNAs) are involved in tumorigenesis and progression in hepatocellular carcinoma (HCC). Among them, miR-645 is recently recognized as cancer-related miRNA and its significance in HCC remains largely unknown. In this study, we reported for the first that miR-645 expression was markedly elevated in HCC tissues and cell lines, and its up-regulation was associated with malignant clinical features, including tumor size and venous infiltration and poor prognosis. Our data revealed that miR-645 promoted cell proliferation, colony formation and inhibited apoptosis by gain- and loss-of function experiments in vitro. In vivo assays showed that miR-645 overexpression enhanced tumor growth. Moreover, miR-645 directly bound to the SOX30 3'-UTR and post-transcriptionally repressed SOX30 expression in HCC cells. Furthermore, miR-645 inversely correlated with SOX30 expression in HCC tissues. Restoration of SOX30 expression at least partially abolished the biological effects of miR-645 on HCC cells. SOX30 regulated HCC progression through aberrant activation of p53 by directly binding to its promoter. Taken together, this research supports the first evidence that miR-645 exerts an oncogenic role in HCC progression and may be a therapeutic target for HCC treatment."xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ijbiomac.2018.10.032"xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/author | "Tao J."xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/author | "Yin G."xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/author | "Tu K."xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/name | "Int J Biol Macromol"xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/pages | "214-222"xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/title | "MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation."xsd:string |
| http://purl.uniprot.org/citations/30312695 | http://purl.uniprot.org/core/volume | "121"xsd:string |
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