| http://purl.uniprot.org/citations/30314757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30314757 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8+ T cell exhaustion impedes control of chronic viral infection; yet how new T cell responses are mounted during chronic infection is unclear. Unlike T cells primed at the onset of infection that rapidly differentiate into effectors and exhaust, we demonstrate that virus-specific CD8+ T cells primed after establishment of chronic LCMV infection preferentially generate memory-like transcription factor TCF1+ cells that were transcriptionally and proteomically distinct, less exhausted, and more responsive to immunotherapy. Mechanistically, adaptations of antigen-presenting cells and diminished T cell signaling intensity promoted differentiation of the memory-like subset at the expense of rapid effector cell differentiation, which was now highly dependent on IL-21-mediated CD4+ T cell help for its functional generation. Chronic viral infection similarly redirected de novo differentiation of tumor-specific CD8+ T cells, ultimately preventing cancer control. Thus, targeting these T cell stimulatory pathways could enable strategies to control chronic infection, tumors, and enhance immunotherapeutic efficacy."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2018.08.002"xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "Law J.C."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "Brooks D.G."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "Guidos C.J."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "Gavin M.A."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "Dickson R.J."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "McGaha T.L."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "Snell L.M."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "Hezaveh K."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "Elsaesser H.J."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "Osokine I."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/author | "MacLeod B.L."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/pages | "678-694.e5"xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/title | "CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity."xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/30314757 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30314757 |
| http://purl.uniprot.org/citations/30314757 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30314757 |
| http://purl.uniprot.org/uniprot/#_P01887-mappedCitation-30314757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30314757 |
| http://purl.uniprot.org/uniprot/#_Q3U679-mappedCitation-30314757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30314757 |
| http://purl.uniprot.org/uniprot/#_Q9D239-mappedCitation-30314757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30314757 |
| http://purl.uniprot.org/uniprot/P01887 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30314757 |