| http://purl.uniprot.org/citations/30315277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30315277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30315277 | http://www.w3.org/2000/01/rdf-schema#comment | "The pre-catalytic spliceosome (B complex) is preceded by its precursor spliceosome (pre-B complex) and followed by the activated spliceosome (Bact complex). The pre-B-to-B and B-to-Bact transitions are driven by the ATPase/helicases Prp28 and Brr2, respectively. In this study, we report the cryo-electron microscopy structures of the human pre-B complex and the human B complex at an average resolution of 5.7 and 3.8 Å, respectively. In the pre-B complex, U1 and U2 small nuclear ribonucleoproteins (snRNPs) associate with two edges of the tetrahedron-shaped U4/U6.U5 tri-snRNP. The pre-mRNA is yet to be recognized by U5 or U6 small nuclear RNA (snRNA), and loop I of U5 snRNA remains unengaged. In the B complex, U1 snRNP and Prp28 are dissociated, the 5'-exon is anchored to loop I of U5 snRNA, and the 5'-splice site is recognized by U6 snRNA through duplex formation. In sharp contrast to S. cerevisiae, most components of U2 snRNP and tri-snRNP, exemplified by Brr2, undergo pronounced rearrangements in the human pre-B-to-B transition. Structural analysis reveals mechanistic insights into the assembly and activation of the human spliceosome."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41422-018-0094-7"xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41422-018-0094-7"xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/author | "Lei J."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/author | "Lei J."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/author | "Zhan X."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/author | "Zhan X."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/author | "Yan C."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/author | "Yan C."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/name | "Cell Res."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/name | "Cell Res."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/pages | "1129-1140"xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/pages | "1129-1140"xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/title | "Structures of the human pre-catalytic spliceosome and its precursor spliceosome."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/title | "Structures of the human pre-catalytic spliceosome and its precursor spliceosome."xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/30315277 | http://purl.uniprot.org/core/volume | "28"xsd:string |