| http://purl.uniprot.org/citations/30316633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30316633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30316633 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous work established a coumarin scaffold as a starting point for inhibition of Mycobacterium tuberculosis (Mtb) FadD32 enzymatic activity. After further profiling of the coumarin inhibitor 4 revealed chemical instability, we discovered that a quinoline ring circumvented this instability and had the advantage of offering additional substitution vectors to further optimize. Ensuing SAR studies gave rise to quinoline-2-carboxamides with potent anti-tubercular activity. Further optimization of ADME/PK properties culminated in 21b that exhibited compelling in vivo efficacy in a mouse model of Mtb infection."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2018.09.037"xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2018.09.037"xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Hubbard B.K."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Hubbard B.K."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Lee K.K."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Lee K.K."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Hung D.T."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Hung D.T."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Yin Y."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Yin Y."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Fisher S."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Fisher S."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Fang C."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Fang C."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Peng Z."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Peng Z."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Barros-Aguirre D."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Barros-Aguirre D."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Bates R.H."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Bates R.H."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Fernandez-Menendez R."xsd:string |
| http://purl.uniprot.org/citations/30316633 | http://purl.uniprot.org/core/author | "Fernandez-Menendez R."xsd:string |