| http://purl.uniprot.org/citations/30317626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30317626 | http://www.w3.org/2000/01/rdf-schema#comment | "The current study was aimed to investigate integrin beta-like 1 (ITGBL1) methylation pattern and its clinical relevance in patients with acute myeloid leukemia (AML). Real-time methylation-specific polymerase chain reaction (PCR; RQ-MSP) and bisulfite sequencing PCR (BSP) were performed to detect the methylation of ITGBL1 promoter. Real-time quantitative PCR (RT-qPCR) was performed to analyze ITGBL1 transcript level. The results showed that ITGBL1 methylation level in 131 patients with AML was significantly higher than 29 controls (p < 0.001). The ITGBL1-hypermethylated group tended to have a higher bone marrow (BM) blasts ( p = 0.076). Meanwhile, ITGBL1-hypermethylated patients tended to have a lower complete remission (CR) rate ( p = 0.102). ITGBL1-hypermethylated patients had significantly shorter overall survival (OS) and leukemia-free survival (LFS) than ITGBL1 hypomethylated patients in whole AML cohort ( p = 0.009 and 0.043, respectively) and patients with nonacute promyelocytic leukemia (APL ; p = 0.023 and 0.039, respectively). Multivariate analysis confirmed that the ITGBL1 methylation served as an independent prognostic factor in both patients with whole-cohort AML ( p = 0.030) and patients with non-APL ( p = 0.020). Furthermore, the ITGBL1 methylation level was significantly decreased in follow-up AML patients who achieved complete remission after induction therapy ( P = 0.001). ITGBL1 methylation negatively correlated with ITGBL1 expression in patients with AML ( R = -0.328, p = 0.008). Moreover, demethylation of ITGBL1 could increase the ITGBL1 expression in the K562 leukemic cell line ( p < 0.05). In conclusion, the ITGBL1 hypermethylation is a potential biomarker for predicting prognosis and monitoring disease status in patients with AML."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.27629"xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Li X.X."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Yan Y."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Wu D.H."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Qian J."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Zhang Z.H."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Ma J.C."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Zhang T.J."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "He P.F."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Zhou J.D."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Deng Z.Q."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/author | "Lian X.Y."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/pages | "9438-9446"xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/title | "Hypermethylation of ITGBL1 is associated with poor prognosis in acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://purl.uniprot.org/core/volume | "234"xsd:string |
| http://purl.uniprot.org/citations/30317626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30317626 |
| http://purl.uniprot.org/citations/30317626 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30317626 |
| http://purl.uniprot.org/uniprot/#_A0A087WY35-mappedCitation-30317626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30317626 |
| http://purl.uniprot.org/uniprot/#_B4DN32-mappedCitation-30317626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30317626 |
| http://purl.uniprot.org/uniprot/#_O14549-mappedCitation-30317626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30317626 |