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http://purl.uniprot.org/citations/30325780http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30325780http://www.w3.org/2000/01/rdf-schema#comment"

Objective

HIV-1 and HIV-2 differ notably in their epidemiology, with worldwide HIV-1 spread and HIV-2 mainly confined to West Africa. Natural killer (NK) cells are critical antiviral effectors of the immune system; however, limited information is available about these innate effector cells during HIV-2 infection.

Method

In this study, 24 untreated HIV-2-infected patients were analyzed and compared with 21 long-term nonprogressor and 10 controller HIV-1 patients, and healthy donors. Extensive phenotype and functional NK-cell characteristics, as well as ligands of activating NK receptors involved in NK lysis were determined by flow cytometry.

Results

We report in HIV-2 patients a very significant reduced expression of the activating NKp30 receptor (P < 0.0001) on NK cells, much higher than observed in HIV-1 patients. The impaired expression of NKp30 is correlated negatively with HLA-DR (r = -0.5970; P = 0.0002), and positively with both NKG2A (r = 0.5324; P < 0.0001) and Siglec-7 (r = 0.5621; P = 0.0004). HIV-2 patients with NKp30 NK cells displayed overproduction of IFN-γ (P < 0.0001) associated with impaired cytolytic function when tested against target cells expressing surface B7-H6. This cellular ligand of NKp30 is strongly detectable as a surface molecule on CD4 T cells infected by HIV-2.

Conclusion

Altogether, our data suggested that the defective expression of NKp30 may be induced by the chronic engagement of this receptor by B7-H6 expressed on HIV-2-infected target cells. This represents a novel mechanism by which the chronic ligand exposure by the viral environment may subvert NK-cell-mediated function to establish persistent HIV-2 infection."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.org/dc/terms/identifier"doi:10.1097/qad.0000000000002061"xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Brun-Vezinet F."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Cheynier R."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Thiebaut R."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Debre P."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Tarantino N."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Vieillard V."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Bayard C."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Samri A."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Matheron S."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Lucar O."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/author"Sadjo Diallo M."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/name"AIDS"xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/pages"23-32"xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/title"B7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape."xsd:string
http://purl.uniprot.org/citations/30325780http://purl.uniprot.org/core/volume"33"xsd:string
http://purl.uniprot.org/citations/30325780http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/30325780
http://purl.uniprot.org/citations/30325780http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/30325780
http://purl.uniprot.org/uniprot/#_A0A1U9X849-mappedCitation-30325780http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30325780
http://purl.uniprot.org/uniprot/#_O14931-mappedCitation-30325780http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30325780
http://purl.uniprot.org/uniprot/#_Q05D23-mappedCitation-30325780http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30325780
http://purl.uniprot.org/uniprot/#_Q68D85-mappedCitation-30325780http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30325780
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