| http://purl.uniprot.org/citations/30327411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30327411 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemokines and some chemical analogs of chemokines prevent cellular HIV-1 entry when bound to the HIV-1 coreceptors C-C chemokine receptor 5 (CCR5) or C-X-C chemokine receptor 4 (CXCR4), which are G protein-coupled receptors (GPCRs). The ideal HIV-1 entry blocker targeting the coreceptors would display ligand bias and avoid activating G protein-mediated pathways that lead to inflammation. We compared CCR5-dependent activation of second messenger pathways in a single cell line. We studied two endogenous chemokines [RANTES (also known as CCL5) and MIP-1α (also known as CCL3)] and four chemokine analogs of RANTES (5P12-, 5P14-, 6P4-, and PSC-RANTES). We found that CCR5 signaled through both Gi/o and Gq/11 IP1 accumulation and Ca2+ flux arose from Gq/11 activation, rather than from Gβγ subunit release after Gi/o activation as had been previously proposed. The 6P4- and PSC-RANTES analogs were superagonists for Gq/11 activation, whereas the 5P12- and 5P14-RANTES analogs displayed a signaling bias for Gi/o These results demonstrate that RANTES analogs elicit G protein subtype-specific signaling bias and can cause CCR5 to couple preferentially to Gq/11 rather than to Gi/o signaling pathways. We propose that G protein subtype-specific signaling bias may be a general feature of GPCRs that can couple to more than one G protein family."xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.aao6152"xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/author | "Berchiche Y.A."xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/author | "Sakmar T.P."xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/author | "Huber T."xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/author | "Lorenzen E."xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/author | "Ceraudo E."xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/author | "Furstenberg A."xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/author | "Rico C.A."xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/pages | "eaao6152"xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/title | "G protein subtype-specific signaling bias in a series of CCR5 chemokine analogs."xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/30327411 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30327411 |
| http://purl.uniprot.org/citations/30327411 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30327411 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S6-mappedCitation-30327411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30327411 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-30327411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30327411 |
| http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-30327411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30327411 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-30327411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30327411 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-30327411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30327411 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G9-mappedCitation-30327411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30327411 |
| http://purl.uniprot.org/uniprot/#_A0A089G3J8-mappedCitation-30327411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30327411 |
| http://purl.uniprot.org/uniprot/#_A0A089G3N4-mappedCitation-30327411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30327411 |