| http://purl.uniprot.org/citations/30328350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30328350 | http://www.w3.org/2000/01/rdf-schema#comment | "A number of sperm proteins are involved in the processes from gamete adhesion to fusion, but the underlying mechanism is still unclear. Here, we established a mouse mutant, the EQUATORIN-knockout (EQTN-KO, Eqtn - / - ) mouse model and found that the EQTN-KO males have reduced fertility and sperm-egg adhesion, while the EQTN-KO females are fertile. Eqtn - / - sperm were normal in morphology and motility. Eqtn - / - -Tg (Acr-Egfp) sperm, which were produced as the acrosome reporter by crossing Eqtn - / - with Eqtn +/+ -Tg(Acr-Egfp) mice, traveled to the oviduct ampulla and penetrated the egg zona pellucida of WT females. However, Eqtn - / - males mated with WT females showed significant reduction in both fertility and the number of sperm attached to the zona-free oocyte. Sperm IZUMO1 and egg CD9 behaved normally in Eqtn - / - sperm when they were fertilized with WT egg. Another acrosomal protein, SPESP1, behaved aberrantly in Eqtn - / - sperm during the acrosome reaction. The fertility impairment of EQTN/SPESP1-double KO males lacking Eqtn and Spesp1 (Eqtn/Spesp1 - / - ) was more severe compared with that of Eqtn - / - males. Eqtn - / - -Tg (Eqtn) males, which were generated to rescue Eqtn - / - males, restored the reduced fertility."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.org/dc/terms/identifier | "doi:10.1530/rep-18-0394"xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/author | "Tamura Y."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/author | "Sugiyama H."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/author | "Ito C."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/author | "Hatano M."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/author | "Toshimori K."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/author | "Fujimura L."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/author | "Miyado K."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/author | "Yamatoya K."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/author | "Suganami A."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/name | "Reproduction"xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/pages | "579-590"xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/title | "Deletion of Eqtn in mice reduces male fertility and sperm-egg adhesion."xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://purl.uniprot.org/core/volume | "156"xsd:string |
| http://purl.uniprot.org/citations/30328350 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30328350 |
| http://purl.uniprot.org/citations/30328350 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30328350 |
| http://purl.uniprot.org/uniprot/#_B7SXT5-mappedCitation-30328350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30328350 |
| http://purl.uniprot.org/uniprot/#_B7SXT6-mappedCitation-30328350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30328350 |
| http://purl.uniprot.org/uniprot/#_P40240-mappedCitation-30328350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30328350 |
| http://purl.uniprot.org/uniprot/#_Q9D9V2-mappedCitation-30328350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30328350 |
| http://purl.uniprot.org/uniprot/#_Q9D5A0-mappedCitation-30328350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30328350 |