| http://purl.uniprot.org/citations/30341289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30341289 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of liver-specific gene expression with potent tumor suppressor activity, yet many liver tumors express HNF4α. This study reveals that P1-HNF4α, the predominant isoform expressed in the adult liver, inhibits expression of tumor promoting genes in a circadian manner. In contrast, an additional isoform of HNF4α, driven by an alternative promoter (P2-HNF4α), is induced in HNF4α-positive human hepatocellular carcinoma (HCC). P2-HNF4α represses the circadian clock gene ARNTL (BMAL1), which is robustly expressed in healthy hepatocytes, and causes nuclear to cytoplasmic re-localization of P1-HNF4α. We reveal mechanisms underlying the incompatibility of BMAL1 and P2-HNF4α in HCC, and demonstrate that forced expression of BMAL1 in HNF4α-positive HCC prevents the growth of tumors in vivo. These data suggest that manipulation of the circadian clock in HNF4α-positive HCC could be a tractable strategy to inhibit tumor growth and progression in the liver."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-06648-6"xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Fu L."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Patel P."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Wang S.H."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Yoo S.H."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Fekry B."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Sun K."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Eckel-Mahan K."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Berdeaux R."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Baumgartner C."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Sladek F.M."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Kwok C."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Kolonin M.G."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Ribas-Latre A."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/author | "Deans J.R."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/pages | "4349"xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/title | "Incompatibility of the circadian protein BMAL1 and HNF4alpha in hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30341289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30341289 |
| http://purl.uniprot.org/citations/30341289 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30341289 |
| http://purl.uniprot.org/uniprot/#_A2ICG8-mappedCitation-30341289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30341289 |