| http://purl.uniprot.org/citations/30343112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30343112 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucleolar protein hUTP14a is required for 18S rRNA processing and promotes p53 degradation. Here, we report that hUTP14a stabilizes c-Myc in colorectal cancer (CRC) progression. Firstly, nucleolar hUTP14a is upregulated in human CRC tissues. Mass spectrometry analysis identified c-Myc and its deubiquitinase ubiquitin-specific protease 36 (USP36) in the hUTP14a-specific complex. Importantly, hUTP14a interacts with c-Myc and protects c-Myc from ubiquitination and degradation in a USP36-dependent way. We further demonstrate that hUTP14a forms a complex with USP36/Fbw7γ to inhibit Fbw7γ-mediated c-Myc degradation. Ectopic expression of Flag-hUTP14a enriches c-Myc in the nucleolus, indicating hUTP14a stabilizes c-Myc in the nucleolus. Interestingly, c-Myc activates transcription of hUTP14a. Knockdown of hUTP14a by short hairpin RNA inhibits tumor growth and decreases c-Myc levels in mouse xenografts. Significantly, nucleolar hUTP14a and c-Myc are co-upregulated in human CRC tissues, and this co-upregulation indicates poor prognosis of CRC patients. Thus, disruption of hUTP14a-c-Myc regulation may provide a potential therapeutic strategy for a subset of CRC patients."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2018.10.010"xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/author | "Xu D."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/author | "Du X."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/author | "Ren P."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/author | "Xing B."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/pages | "106-115"xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/title | "Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc."xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://purl.uniprot.org/core/volume | "440-441"xsd:string |
| http://purl.uniprot.org/citations/30343112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30343112 |
| http://purl.uniprot.org/citations/30343112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30343112 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-30343112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30343112 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-30343112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30343112 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-30343112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30343112 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-30343112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30343112 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-30343112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30343112 |