| http://purl.uniprot.org/citations/30348529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30348529 | http://www.w3.org/2000/01/rdf-schema#comment | "Researchers have shown that long noncoding RNAs (lncRNAs) are closely associated with the pathogenesis of colorectal cancer (CRC). In here, we aimed to explore the function of lncRNA MAFG-AS1 in tumorigenesis of CRC. Firstly, we found that the expression of MAFG-AS1 was upregulated in CRC tissues and positively correlated with the advanced tumor stage. A reciprocal repression was found between MAFG-AS1 and miR-147b. The expression of miR-147b was downregulated in CRC tissues and inversely correlated with MAFG-AS1. Both the low-expression of miR-147b expression and the advanced tumor stage were independent factor for poor survival probability. Furthermore, overexpression of MAFG-AS1 promoted cell proliferation, cell cycle progression, and invasion, and inhibited apoptosis, while transduction of miR-147b partially reversed the effect of MAFG-AS1 on cellular processes. Consistently, stable over-expression of MAFG-AS1 contributed to the growth of colon cancer cell xenografts in vivo. NDUFA4 was identified as a direct target of miR-147b and knockdown of NDUFA4 abolished the oncogenic role of miR-147b inhibitor. Besides, MAFG-AS1 contributed to cell glycolysis by sponging miR-147b and activation of NDUFA4, causing an upregulation of PDK1, PFK1 and PKM2. Taken together, our study suggested that MAFG-AS1 functions as a novel oncogenic lncRNA in the development of CRC by regulating miR-147b/NDUFA4."xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.10.112"xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://purl.uniprot.org/core/author | "Cui S."xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://purl.uniprot.org/core/author | "Yan W."xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30348529 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://purl.uniprot.org/core/pages | "251-258"xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://purl.uniprot.org/core/title | "LncRNA MAFG-AS1 promotes the progression of colorectal cancer by sponging miR-147b and activation of NDUFA4."xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://purl.uniprot.org/core/volume | "506"xsd:string |
| http://purl.uniprot.org/citations/30348529 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30348529 |
| http://purl.uniprot.org/citations/30348529 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30348529 |
| http://purl.uniprot.org/uniprot/#_O00483-mappedCitation-30348529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30348529 |
| http://purl.uniprot.org/uniprot/O00483 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30348529 |