| http://purl.uniprot.org/citations/30349023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30349023 | http://www.w3.org/2000/01/rdf-schema#comment | "TNF-like weak inducer of apoptosis (TWEAK) and inhibition of protein synthesis with cycloheximide (CHX) sensitize for poly(I:C)-induced cell death. Notably, although CHX preferentially enhanced poly(I:C)-induced apoptosis, TWEAK enhanced primarily poly(I:C)-induced necroptosis. Both sensitizers of poly(I:C)-induced cell death, however, showed no major effect on proinflammatory poly(I:C) signaling. Analysis of a panel of HeLa-RIPK3 variants lacking TRADD, RIPK1, FADD, or caspase-8 expression revealed furthermore similarities and differences in the way how poly(I:C)/TWEAK, TNF, and TRAIL utilize these molecules for signaling. RIPK1 turned out to be essential for poly(I:C)/TWEAK-induced caspase-8-mediated apoptosis but was dispensable for this response in TNF and TRAIL signaling. TRADD-RIPK1-double deficiency differentially affected poly(I:C)-triggered gene induction but abrogated gene induction by TNF completely. FADD deficiency abrogated TRAIL- but not TNF- and poly(I:C)-induced necroptosis, whereas TRADD elicited protective activity against all three death inducers. A general protective activity against poly(I:C)-, TRAIL-, and TNF-induced cell death was also observed in FLIPL and FLIPS transfectrants."xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-018-1137-1"xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/author | "Rosenthal A."xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/author | "Wajant H."xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/author | "Otto C."xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/author | "Siegmund D."xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/author | "Anany M.A."xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/author | "Fullsack S."xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/author | "Kreckel J."xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/pages | "1084"xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/title | "Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis."xsd:string |
| http://purl.uniprot.org/citations/30349023 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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