| http://purl.uniprot.org/citations/30353006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30353006 | http://www.w3.org/2000/01/rdf-schema#comment | "TDP-43 is the major disease protein associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-TDP). Here we identify the transcriptional elongation factor Ell-a shared component of little elongation complex (LEC) and super elongation complex (SEC)-as a strong modifier of TDP-43-mediated neurodegeneration. Our data indicate select targets of LEC and SEC become upregulated in the fly ALS/FTLD-TDP model. Among them, U12 snRNA and a stress-induced long non-coding RNA Hsrω, functionally contribute to TDP-43-mediated degeneration. We extend the findings of Hsrω, which we identify as a chromosomal target of TDP-43, to show that the human orthologue Sat III is elevated in a human cellular disease model and FTLD-TDP patient tissue. We further demonstrate an interaction between TDP-43 and human ELL2 by co-immunoprecipitation from human cells. These findings reveal important roles of Ell-complexes LEC and SEC in TDP-43-associated toxicity, providing potential therapeutic insight for TDP-43-associated neurodegeneration."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-06543-0"xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Chung C.Y."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Unger T."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Shilatifard A."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Smith E.R."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Lee V.M."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Bonini N.M."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Kennerdell J.R."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Chen-Plotkin A."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Van Deerlin V."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Berson A."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Porta S."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/author | "Sartoris A."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/pages | "4406"xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/title | "Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity."xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30353006 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30353006 |
| http://purl.uniprot.org/citations/30353006 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30353006 |
| http://purl.uniprot.org/uniprot/#_D5SHT8-mappedCitation-30353006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30353006 |
| http://purl.uniprot.org/uniprot/#_A0A1W5PXG3-mappedCitation-30353006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30353006 |