| http://purl.uniprot.org/citations/30354252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30354252 | http://www.w3.org/2000/01/rdf-schema#comment | "Objective-Deep vein thrombosis results from a combination of risk factors including genetic conditions, obesity, drugs, pregnancy, aging, and malignancy. We examined pathophysiological roles of the TNF-α (tumor necrosis factor-α)-TNF-Rp55 (tumor necrosis factor receptor p55) axis in thrombus resolution using Tnfrp55-/- (TNF-Rp55-deficient) mice. Approach and Results-On ligating the inferior vena cava of wild-type (WT) mice, venous thrombi formed and grew progressively until 5 days but shrunk to <50% of the thrombus weight at day 14. Concomitantly, inferior vena cava ligation enhanced intrathrombotic gene expression of Tnfa and Tnfrp55, and intrathrombotic macrophages expressed both TNF-α and TNF-Rp55 proteins. In Tnfrp55-/- mice treated with the same manner, thrombus formed at a similar rate for 5 days, but shrinking was delayed compared with WT mice. Moreover, the blood flow recovery in thrombosed inferior vena cava was suspended in Tnfrp55-/- mice compared with WT mice. Intrathrombotic Plau (urokinase-type plasminogen activator), Mmp2 (matrix metalloproteinase 2), and Mmp9 (matrix metalloproteinase 9) mRNA expression was significantly reduced in Tnfrp55-/- mice, compared with WT ones. Supportingly, the administration of anti-TNF-α antibody or TNF-α inhibitor (etanercept) delayed the thrombus resolution in WT mice. Furthermore, TNF-α treatment enhanced gene expression of Plau, Mmp2, and Mmp9 in WT macrophages but not Tnfrp55-/- macrophages. These effects were significantly suppressed by ERK (extracellular signal regulated kinase) and NF-κB (nuclear factor-kappa B) inhibitors. Therefore, the lack of TNF-Rp55 has detrimental roles in the thrombus resolution by suppressing PLAU, MMP-2, and MMP-9 expression. In contrast, TNF-α administration accelerated thrombus resolution in WT but not Tnfrp55-/- mice. Conclusions-The TNF-α-TNF-Rp55 axis may have essential roles in the resolution of venous thrombus in mice."xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.org/dc/terms/identifier | "doi:10.1161/atvbaha.118.311194"xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/author | "Ishida Y."xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/author | "Furuta M."xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/author | "Kimura A."xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/author | "Nosaka M."xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/author | "Mukaida N."xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/author | "Kuninaka Y."xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/author | "Taruya A."xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/name | "Arterioscler Thromb Vasc Biol"xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/pages | "2638-2650"xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/title | "Contribution of the TNF-alpha (Tumor Necrosis Factor-alpha)-TNF-Rp55 (Tumor Necrosis Factor Receptor p55) Axis in the Resolution of Venous Thrombus."xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/30354252 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30354252 |
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| http://purl.uniprot.org/uniprot/#_P25118-mappedCitation-30354252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30354252 |