| http://purl.uniprot.org/citations/30355497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30355497 | http://www.w3.org/2000/01/rdf-schema#comment | "Monoclonal antibodies (mAbs) targeting the co-stimulatory molecule 4-1BB are of interest for tumor immunotherapy. We determined the complex structures of human 4-1BB with 4-1BB ligand (4-1BBL) or utomilumab to elucidate the structural basis of 4-1BB activation. The 4-1BB/4-1BBL complex displays a typical TNF/TNFR family binding mode. The structure of utomilumab/4-1BB complex shows that utomilumab binds to dimeric 4-1BB with a distinct but partially overlapping binding area with 4-1BBL. Competitive binding analysis demonstrates that utomilumab blocks the 4-1BB/4-1BBL interaction, indicating the interruption of ligand-mediated signaling. The binding profiles of 4-1BBL and utomilumab to monomeric or dimeric 4-1BB indicate limited cross-linking of 4-1BB molecules. These findings provide mechanistic insight into the binding of 4-1BB with its ligand and its agonist mAb, which may facilitate the future development of anti-4-1BB biologics for tumor immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.09.073"xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Gao G.F."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "He M."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Lei Y."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Gao S."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Qi J."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Tian Z."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Tong Z."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Tien P."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Liu K."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Chai Y."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Tan S."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Liu W.J."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/author | "Zhang C.W."xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/30355497 | http://purl.uniprot.org/core/pages | "909-920.e4"xsd:string |