| http://purl.uniprot.org/citations/30356330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30356330 | http://www.w3.org/2000/01/rdf-schema#comment | "Programmed cell death-1 (PD-1) is an inhibitory immune checkpoint receptor that negatively regulates the functioning of T cell. Although the direct targets of PD-1 were not identified, its inhibitory action on the TCR signaling pathway was known much earlier. Recent experiments suggest that the PD-1 inhibits the TCR and CD28 signaling pathways at a very early stage ─ at the level of phosphorylation of the cytoplasmic domain of TCR and CD28 receptors. Here, we develop a mathematical model to investigate the influence of inhibitory effect of PD-1 on the activation of early TCR and CD28 signaling molecules. Proposed model recaptures several quantitative experimental observations of PD-1 mediated inhibition. Model simulations show that PD-1 imposes a net inhibitory effect on the Lck kinase. Further, the inhibitory effect of PD-1 on the activation of TCR signaling molecules such as Zap70 and SLP76 is significantly enhanced by the PD-1 mediated inhibition of Lck. These results suggest a critical role for Lck as a mediator for PD-1 induced inhibition of TCR signaling network. Multi parametric sensitivity analysis explores the effect of parameter uncertainty on model simulations."xsd:string |
| http://purl.uniprot.org/citations/30356330 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0206232"xsd:string |
| http://purl.uniprot.org/citations/30356330 | http://purl.uniprot.org/core/author | "Barik D."xsd:string |
| http://purl.uniprot.org/citations/30356330 | http://purl.uniprot.org/core/author | "Arulraj T."xsd:string |
| http://purl.uniprot.org/citations/30356330 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30356330 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/30356330 | http://purl.uniprot.org/core/pages | "e0206232"xsd:string |
| http://purl.uniprot.org/citations/30356330 | http://purl.uniprot.org/core/title | "Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling."xsd:string |
| http://purl.uniprot.org/citations/30356330 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/30356330 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30356330 |
| http://purl.uniprot.org/citations/30356330 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30356330 |
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| http://purl.uniprot.org/uniprot/#_A0A0M3M0G7-mappedCitation-30356330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30356330 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3T3-mappedCitation-30356330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30356330 |
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| http://purl.uniprot.org/uniprot/#_B3KUV3-mappedCitation-30356330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30356330 |
| http://purl.uniprot.org/uniprot/#_B4DZS7-mappedCitation-30356330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30356330 |
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| http://purl.uniprot.org/uniprot/#_Q573B4-mappedCitation-30356330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30356330 |
| http://purl.uniprot.org/uniprot/#_P43403-mappedCitation-30356330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30356330 |
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| http://purl.uniprot.org/uniprot/#_Q7Z5I0-mappedCitation-30356330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30356330 |
| http://purl.uniprot.org/uniprot/#_Q9UMF3-mappedCitation-30356330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30356330 |