| http://purl.uniprot.org/citations/30361090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30361090 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila Toll-1 receptor is involved in embryonic development, innate immunity, and tissue homeostasis. Currently, as a ligand for the Toll-1 receptor, only Spätzle (Spz) has been identified and characterized. We previously reported that Drosophila larva-derived tissue extract contains ligand activity for the Toll-1 receptor, which differs from Spz based on the observation that larval extract prepared from spz mutants possessed full ligand activity. Here, we demonstrate that Spz5, a member of the Spz family of proteins, functions as a ligand for the Toll-1 receptor. Processing of Spz5 by Furin protease, which is known to be important for ligand activity of Spz5 to Toll-6, is not required for its function to the Toll-1 receptor. By generating a spz5 null mutant, we further showed that the Toll-1 ligand activity of larva-derived extract is mainly derived from Spz5. Finally, we found a genetic interaction between spz and spz5 in terms of developmental processes. This study identified a novel ligand for the Drosophila Toll-1 receptor, providing evidence that Toll-1 is a multi-ligand receptor, similar to the mammalian Toll-like receptor."xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.10.096"xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/author | "Fukushima K."xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/author | "Nakanishi Y."xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/author | "Hori A."xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/author | "Kawamura K."xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/author | "Kuraishi T."xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/author | "Salim E."xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/author | "Nonaka S."xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/pages | "510-515"xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/title | "Characterization of Spz5 as a novel ligand for Drosophila Toll-1 receptor."xsd:string |
| http://purl.uniprot.org/citations/30361090 | http://purl.uniprot.org/core/volume | "506"xsd:string |
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