| http://purl.uniprot.org/citations/30361438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30361438 | http://www.w3.org/2000/01/rdf-schema#comment | "The linear ubiquitin chain assembly complex (LUBAC) regulates NF-κB activation by modifying proteins with linear (M1-linked) ubiquitination chains. Although LUBAC also regulates the apoptosis pathway, the precise mechanism by which LUBAC regulates apoptosis remains not fully defined. Here, we report that LUBAC-mediated M1-linked ubiquitination of cellular FLICE-like inhibitory protein (cFLIP), an anti-apoptotic molecule, contributes to tumor necrosis factor (TNF) α-induced apoptosis. We found that deficiency of RNF31, the catalytic subunit of the LUBAC complex, promoted cFLIP degradation in a proteasome-dependent manner. Moreover, we observed RNF31 directly interact with cFLIP, and LUBAC further conjugated M1-linked ubiquitination chains at Lys-351 and Lys-353 of cFLIP to stabilize cFLIP, thereby protecting cells from TNFα-induced apoptosis. Together, our study identifies a new substrate of LUBAC and reveals a new molecular mechanism through which LUBAC regulates TNFα-induced apoptosis via M1-linked ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra118.005449"xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/author | "Liu G."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/author | "Tu H."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/author | "You J."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/author | "Joo D."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/pages | "20062-20072"xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/title | "Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFalpha-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/30361438 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30361438 |
| http://purl.uniprot.org/citations/30361438 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30361438 |
| http://purl.uniprot.org/uniprot/#_A0A024R3Y4-mappedCitation-30361438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30361438 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-30361438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30361438 |
| http://purl.uniprot.org/uniprot/#_E9PAP3-mappedCitation-30361438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30361438 |
| http://purl.uniprot.org/uniprot/#_A0A336TY74-mappedCitation-30361438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30361438 |
| http://purl.uniprot.org/uniprot/#_A0A411D318-mappedCitation-30361438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30361438 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X8M9-mappedCitation-30361438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30361438 |