| http://purl.uniprot.org/citations/3036526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3036526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3036526 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe the complete sequence of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein. The coding sequence is interrupted by two intervening sequences which align perfectly with the first two intervening sequences in the gene encoding NF-L (the low-molecular-mass neurofilament protein); there is no intron in the gene encoding NF-M corresponding to the third intron in NF-L. Therefore, both the number of introns and their arrangement in the genes coding NF-L and NF-M contrast sharply with the number and arrangement of introns in the genes of known sequence, encoding other members of the intermediate filament multigene family (desmin, vimentin, glial fibrillary acidic protein and the acidic and basic keratins); with the exception of a single truncated keratin gene that lacks an encoded tailpiece, these genes all contain eight introns, of which at least six are placed at homologous locations. Assuming the existence of a primordial intermediate filament gene containing most (if not all) the introns found in contemporary non-neurofilament intermediate filament genes, it seems likely that an RNA-mediated transposition event was involved in the generation of an ancestral gene encoding the NF polypeptides. A combination of insertional transposition and gene-duplication events could then explain the anomalous number and placement of introns within these genes. Consistent with this notion, we show that the genes encoding NF-M and NF-L are linked."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1987.tb13485.x"xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1987.tb13485.x"xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/author | "Cowan N.J."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/author | "Cowan N.J."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/author | "D'Eustachio P."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/author | "D'Eustachio P."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/author | "Levy E."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/author | "Levy E."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/author | "Liem R.K.H."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/author | "Liem R.K.H."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/pages | "71-77"xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/pages | "71-77"xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/title | "Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/title | "Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein."xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/3036526 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3036526 |
| http://purl.uniprot.org/citations/3036526 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3036526 |