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http://purl.uniprot.org/citations/3036660http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3036660http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3036660http://www.w3.org/2000/01/rdf-schema#comment"To examine the genetic relatedness of human immunodeficiency viruses (HIV) from different geographic locations, we molecularly cloned the genome of HIV isolated from a Zairian AIDS patient. Restriction mapping of the recombinant clone, designated HIV-Zr6, revealed both common (as observed in other HIV isolates) and unique restriction sites. The DNA clone of HIV-Zr6, shown to give rise to infectious cytopathic virus after transfection of cultured lymphoid cells, was sequenced in several regions. The long terminal repeat (LTR), open reading frame 1 (ORF1), C-terminal envelope (env) gene domain, and ORF2 showed less than 6% difference in nucleotide sequence when compared to other HIV isolates including human T-lymphotropic virus-type III (HTLV-III) clone B10, lymphadenopathy-associated virus-1 (LAV-1), and AIDS-associated retrovirus-2 (ARV-2). About 15% difference in nucleotide sequences was noted in the N-terminal env gene domain. Alignments of env gene sequences revealed conserved, moderately variable, and hypervariable stretches in the predicted amino acid sequences. This model provides a basis for assessing the significance of sequence variation on properties controlled by the viral Env glycoproteins such as cell tropism and immunogenicity."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.org/dc/terms/identifier"doi:10.1016/0378-1119(87)90396-9"xsd:string
http://purl.uniprot.org/citations/3036660http://purl.org/dc/terms/identifier"doi:10.1016/0378-1119(87)90396-9"xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Luciw P.A."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Luciw P.A."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Srinivasan A."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Srinivasan A."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Anand R."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Anand R."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Sanchez-Pescador R."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Sanchez-Pescador R."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Curran J."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Curran J."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Feorino P."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Feorino P."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Kalyanaraman V.S."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Kalyanaraman V.S."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Ranganathan P."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Ranganathan P."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Schochetman G."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"Schochetman G."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"York D."xsd:string
http://purl.uniprot.org/citations/3036660http://purl.uniprot.org/core/author"York D."xsd:string