| http://purl.uniprot.org/citations/30366904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30366904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30366904 | http://www.w3.org/2000/01/rdf-schema#comment | "Bcl9 and Pygopus (Pygo) are obligate Wnt/β-catenin cofactors in Drosophila, yet their contribution to Wnt signaling during vertebrate development remains unresolved. Combining zebrafish and mouse genetics, we document a conserved, β-catenin-associated function for BCL9 and Pygo proteins during vertebrate heart development. Disrupting the β-catenin-BCL9-Pygo complex results in a broadly maintained canonical Wnt response yet perturbs heart development and proper expression of key cardiac regulators. Our work highlights BCL9 and Pygo as selective β-catenin cofactors in a subset of canonical Wnt responses during vertebrate development. Moreover, our results implicate alterations in BCL9 and BCL9L in human congenital heart defects."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.315531.118"xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Burger A."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Burger A."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Basler K."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Basler K."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Chiavacci E."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Chiavacci E."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Aguet M."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Aguet M."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Panakova D."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Panakova D."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Burger S."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Burger S."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Hausmann G."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Hausmann G."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Mosimann C."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Mosimann C."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Valenta T."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Valenta T."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Felker A."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Felker A."xsd:string |
| http://purl.uniprot.org/citations/30366904 | http://purl.uniprot.org/core/author | "Kirchgeorg L."xsd:string |