| http://purl.uniprot.org/citations/30367035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30367035 | http://www.w3.org/2000/01/rdf-schema#comment | "Myoblast fusion is tightly regulated during development and regeneration of muscle fibers. BAI3 is a receptor that orchestrates myoblast fusion via Elmo/Dock1 signaling, but the mechanisms regulating its activity remain elusive. Here we report that mice lacking BAI3 display small muscle fibers and inefficient muscle regeneration after cardiotoxin-induced injury. We describe two proteins that repress or activate BAI3 in muscle progenitors. We find that the secreted C1q-like1-4 proteins repress fusion by specifically interacting with BAI3. Using a proteomic approach, we identify Stabilin-2 as a protein that interacts with BAI3 and stimulates its fusion promoting activity. We demonstrate that Stabilin-2 activates the GPCR activity of BAI3. The resulting activated heterotrimeric G-proteins contribute to the initial recruitment of Elmo proteins to the membrane, which are then stabilized on BAI3 through a direct interaction. Collectively, our results demonstrate that the activity of BAI3 is spatiotemporally regulated by C1qL4 and Stabilin-2 during myoblast fusion."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-06897-5"xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Pelletier A."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Bouvier M."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Tran V."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Aimi T."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Cote J.F."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Wong G.W."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Kim I.S."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Hamoud N."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Kania A."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Kakegawa W."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Yuzaki M."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Thibault M.P."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/author | "Lahaie S."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/pages | "4470"xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/title | "Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion."xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30367035 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30367035 |
| http://purl.uniprot.org/citations/30367035 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30367035 |
| http://purl.uniprot.org/uniprot/#_Q0PNF1-mappedCitation-30367035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30367035 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6Y4-mappedCitation-30367035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30367035 |