| http://purl.uniprot.org/citations/30375383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30375383 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysregulated ROR-γt-mediated IL-17 transcription is central to the pathogenesis of several inflammatory disorders, yet the molecular mechanisms that govern the transcription factor activity of ROR-γt in the regulation of IL-17 are not fully defined. Here we show that SUMO-conjugating enzyme Ubc9 interacts with a conserved GKAE motif in ROR-γt to induce SUMOylation of ROR-γt and suppress IL-17 expression. Th17 cells expressing SUMOylation-defective ROR-γt are highly colitogenic upon transfer to Rag1-/- mice. Mechanistically, SUMOylation of ROR-γt facilitates the binding of HDAC2 to the IL-17 promoter and represses IL-17 transcription. Mice with conditional deletion of HDAC2 in CD4+ T cells have elevated IL-17 expression and severe colitis. The identification of the Ubc9/ROR-γt/HDAC2 axis that governs IL-17 expression may open new venues for the development of therapeutic measures for inflammatory disorders."xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-06924-5"xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/author | "Singh A.K."xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/author | "Basrur V."xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/author | "DePinho R.A."xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/author | "Venuprasad K."xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/author | "Conlon K.P."xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/author | "Obaid A."xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/author | "Khare P."xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/pages | "4515"xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/title | "SUMOylation of ROR-gammat inhibits IL-17 expression and inflammation via HDAC2."xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30375383 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30375383 |
| http://purl.uniprot.org/citations/30375383 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30375383 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGZ6-mappedCitation-30375383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30375383 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J008-mappedCitation-30375383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30375383 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J096-mappedCitation-30375383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30375383 |
| http://purl.uniprot.org/uniprot/#_G3UWJ1-mappedCitation-30375383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30375383 |
| http://purl.uniprot.org/uniprot/#_G3UWL6-mappedCitation-30375383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30375383 |
| http://purl.uniprot.org/uniprot/#_G3UZL6-mappedCitation-30375383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30375383 |
| http://purl.uniprot.org/uniprot/#_G3UYP0-mappedCitation-30375383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30375383 |
| http://purl.uniprot.org/uniprot/#_Q3UUW3-mappedCitation-30375383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30375383 |