| http://purl.uniprot.org/citations/30377265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30377265 | http://www.w3.org/2000/01/rdf-schema#comment | "Janus tyrosine kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling pathway is essential for modulating cellular development, differentiation, and homeostasis. Thus, dysregulation of JAK2-STAT3 signaling pathway is frequently associated with human malignancies. Here, we provide evidence that lysine-specific demethylase 3A (KDM3A) functions as an essential epigenetic enzyme for the activation of JAK2-STAT3 signaling pathway. KDM3A is tyrosine-phosphorylated by JAK2 in the nucleus and functions as a STAT3-dependent transcriptional coactivator. JAK2-KDM3A signaling cascade induced by IL-6 leads to alteration of histone H3K9 methylation as a predominant epigenetic event, thereby providing the functional and mechanistic link between activation of JAK2-STAT3 signaling pathway and its epigenetic control. Together, our findings demonstrate that inhibition of KDM3A phosphorylation could be a potent therapeutic strategy to control oncogenic effect of JAK2-STAT3 signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1805662115"xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Kim D."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Oh S.K."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Yoon J.B."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Baek S.H."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Choi S.A."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Pyo K.E."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/author | "Kim C.R."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/pages | "11766-11771"xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/title | "KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/30377265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30377265 |
| http://purl.uniprot.org/citations/30377265 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30377265 |
| http://purl.uniprot.org/uniprot/#_B4E2H5-mappedCitation-30377265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30377265 |
| http://purl.uniprot.org/uniprot/#_Q9Y4C1-mappedCitation-30377265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30377265 |
| http://purl.uniprot.org/uniprot/Q9Y4C1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30377265 |
| http://purl.uniprot.org/uniprot/B4E2H5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30377265 |