| http://purl.uniprot.org/citations/30380731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30380731 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, muscle-invasive bladder cancer (MIBC) has been subclassified by gene expression profiling, with a substantial impact on therapy response and patient outcome. We tested whether these complex molecular subtypes of MIBC can be determined by mRNA detection of keratin 5 (KRT5) and keratin 20 (KRT20). Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) was applied to quantify gene expression of KRT5 and KRT20 using TaqMan®-based assays in 122 curatively treated MIBC patients (median age 68.0 years). Furthermore, in silico analysis of the MD Anderson Cancer Center (MDACC) cohort (GSE48277 + GSE47993) was performed. High expression of KRT5 and low expression of KRT20 were associated with significantly improved recurrence-free survival (RFS) and disease-specific survival disease specific survival (DSS: 5-year DSS for KRT5 high: 58%; 5-year DSS for KRT20 high: 29%). KRT5 and KRT20 were associated with rates of lymphovascular invasion and lymphonodal metastasis. The combination of KRT5 and KRT20 allowed identification of patients with a very poor prognosis (KRT20⁺/KRT5-, 5-year DSS 0%, p < 0.0001). In silico analysis of the independent MDACC cohorts revealed congruent results (5-year DSS for KRT20 low vs. high: 84% vs. 40%, p = 0.042). High KRT20-expressing tumors as well as KRT20⁺/KRT- tumors were significantly enriched with aggressive urothelial carcinoma variants (micropapillary, plasmacytoid, nested)."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms19113396"xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Porubsky S."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Hartmann A."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Stoehr R."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Burger M."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Nitschke K."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Keck B."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Eckstein M."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Erben P."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Otto W."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Breyer J."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Wirtz R.M."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Bolenz C."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Eidt S."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Sikic D."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/author | "Gross-Weege M."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/pages | "E3396"xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/title | "mRNA-Expression of KRT5 and KRT20 Defines Distinct Prognostic Subgroups of Muscle-Invasive Urothelial Bladder Cancer Correlating with Histological Variants."xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/30380731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30380731 |
| http://purl.uniprot.org/citations/30380731 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30380731 |