| http://purl.uniprot.org/citations/30381458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30381458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30381458 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ, thereby silencing cytokine expression while activating caspase-8-mediated cell death. Here, using Yersinia pseudotuberculosis in corroboration with costimulation of lipopolysaccharide and (5Z)-7-Oxozeaenol, a small-molecule inhibitor of TAK1, we show that caspase-8 activation during TAK1 inhibition results in cleavage of both gasdermin D (GSDMD) and gasdermin E (GSDME) in murine macrophages, resulting in pyroptosis. Loss of GsdmD delays membrane rupture, reverting the cell-death morphology to apoptosis. We found that the Yersinia-driven IL-1 response arises from asynchrony of macrophage death during bulk infections in which two cellular populations are required to provide signal 1 and signal 2 for IL-1α/β release. Furthermore, we found that human macrophages are resistant to YopJ-mediated pyroptosis, with dampened IL-1β production. Our results uncover a form of caspase-8-mediated pyroptosis and suggest a hypothesis for the increased sensitivity of humans to Yersinia infection compared with the rodent reservoir."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1809548115"xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1809548115"xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Shao F."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Shao F."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Tang A.Y."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Tang A.Y."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Bunnell S.C."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Bunnell S.C."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Liu B.C."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Liu B.C."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Muendlein H.I."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Muendlein H.I."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Nilson R."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Nilson R."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Poltorak A."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Poltorak A."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Rongvaux A."xsd:string |
| http://purl.uniprot.org/citations/30381458 | http://purl.uniprot.org/core/author | "Rongvaux A."xsd:string |