| http://purl.uniprot.org/citations/30382939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30382939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30382939 | http://www.w3.org/2000/01/rdf-schema#comment | "Mechanically activated ion channels underlie touch, hearing, shear-stress sensing, and response to turgor pressure. OSCA/TMEM63s are a newly-identified family of eukaryotic mechanically activated ion channels opened by membrane tension. The structural underpinnings of OSCA/TMEM63 function are not explored. Here, we elucidate high resolution cryo-electron microscopy structures of OSCA1.2, revealing a dimeric architecture containing eleven transmembrane helices per subunit and surprising topological similarities to TMEM16 proteins. We locate the ion permeation pathway within each subunit by demonstrating that a conserved acidic residue is a determinant of channel conductance. Molecular dynamics simulations reveal membrane interactions, suggesting the role of lipids in OSCA1.2 gating. These results lay a foundation to decipher how the structural organization of OSCA/TMEM63 is suited for their roles as MA ion channels."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.41845"xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.41845"xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Ward A.B."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Ward A.B."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Sansom M.S."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Sansom M.S."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Jojoa-Cruz S."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Jojoa-Cruz S."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Murthy S.E."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Murthy S.E."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Patapoutian A."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Patapoutian A."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Saotome K."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Saotome K."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Tsui C.C.A."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/author | "Tsui C.C.A."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/title | "Cryo-EM structure of the mechanically activated ion channel OSCA1.2."xsd:string |
| http://purl.uniprot.org/citations/30382939 | http://purl.uniprot.org/core/title | "Cryo-EM structure of the mechanically activated ion channel OSCA1.2."xsd:string |