| http://purl.uniprot.org/citations/30388411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30388411 | http://www.w3.org/2000/01/rdf-schema#comment | "Recursive splicing (RS) starts by defining an "RS-exon," which is then spliced to the preceding exon, thus creating a recursive 5' splice site (RS-5ss). Previous studies focused on cryptic RS-exons, and now we find that the exon junction complex (EJC) represses RS of hundreds of annotated, mainly constitutive RS-exons. The core EJC factors, and the peripheral factors PNN and RNPS1, maintain RS-exon inclusion by repressing spliceosomal assembly on RS-5ss. The EJC also blocks 5ss located near exon-exon junctions, thus repressing inclusion of cryptic microexons. The prevalence of annotated RS-exons is high in deuterostomes, while the cryptic RS-exons are more prevalent in Drosophila, where EJC appears less capable of repressing RS. Notably, incomplete repression of RS also contributes to physiological alternative splicing of several human RS-exons. Finally, haploinsufficiency of the EJC factor Magoh in mice is associated with skipping of RS-exons in the brain, with relevance to the microcephaly phenotype and human diseases."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2018.09.033"xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Irimia M."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Ule J."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Sibley C.R."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Emmett W."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Bradley R.K."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Gohr A."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Blazquez L."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Haberman N."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Bajew S."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Faraway R."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/author | "Pineda J.M.B."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/pages | "496-509.e9"xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/title | "Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing."xsd:string |
| http://purl.uniprot.org/citations/30388411 | http://purl.uniprot.org/core/volume | "72"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q62150-mappedCitation-30388411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30388411 |
| http://purl.uniprot.org/uniprot/#_O35691-mappedCitation-30388411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30388411 |