| http://purl.uniprot.org/citations/30391495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30391495 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAtrogin1, which is one of the key genes for the promotion of muscle atrophy, exhibits day-night variation. However, its mechanism and the role of its day-night variation are largely unknown in a muscle atrophic context.MethodsThe mice were induced a muscle atrophy by hindlimb-unloading (HU). To examine a role of circadian clock, Wild-type (WT) and Clock mutant mice were used. To test the effects of a neuronal effects, an unilateral ablation of sciatic nerve was performed in HU mice. To test a timing-dependent effects of weight-bearing, mice were released from HU for 4 h in a day at early or late active phase (W-EAP and W-LAP groups, respectively).FindingsWe found that the day-night oscillation of Atrogin1 expression was not observed in Clock mutant mice or in the sciatic denervated muscle. In addition, the therapeutic effects of weight-bearing were dependent on its timing with a better effect in the early active phase.InterpretationThese findings suggest that the circadian clock controls the day-night oscillation of Atrogin1 expression and the therapeutic effects of weight-bearing are dependent on its timing. FUND: Council for Science, Technology, and Innovation, SIP, "Technologies for creating next-generation agriculture, forestry, and fisheries"."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ebiom.2018.10.057"xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Aoki N."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Ishikawa R."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Kojima S."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Shibata S."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Sasaki K."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Shimoda T."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Hattori Y."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Hirooka R."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Takizawa M."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Aoyama S."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/author | "Haraguchi A."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/name | "EBioMedicine"xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/pages | "499-508"xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/title | "Day-Night Oscillation of Atrogin1 and Timing-Dependent Preventive Effect of Weight-Bearing on Muscle Atrophy."xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/30391495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30391495 |
| http://purl.uniprot.org/citations/30391495 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30391495 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU61-mappedCitation-30391495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30391495 |
| http://purl.uniprot.org/uniprot/#_O08785-mappedCitation-30391495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30391495 |