| http://purl.uniprot.org/citations/30392829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30392829 | http://www.w3.org/2000/01/rdf-schema#comment | "Viral persistence can contribute to chronic disease and promote virus dissemination. Prior work demonstrated that timely clearance of systemic murine norovirus (MNV) infection depends on cell-intrinsic type I interferon responses and adaptive immunity. We now find that the capsid of the systemically replicating MNV strain CW3 promotes lytic cell death, release of interleukin-1α, and increased inflammatory cytokine release. Correspondingly, inflammatory monocytes and neutrophils are recruited to sites of infection in a CW3-capsid-dependent manner. Recruited monocytes and neutrophils are subsequently infected, representing a majority of infected cells in vivo. Systemic depletion of inflammatory monocytes or neutrophils from persistently infected Rag1-/- mice reduces viral titers in a tissue-specific manner. These data indicate that the CW3 capsid facilitates lytic cell death, inflammation, and recruitment of susceptible cells to promote persistence. Infection of continuously recruited inflammatory cells may be a mechanism of persistence broadly utilized by lytic viruses incapable of establishing latency."xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2018.10.003"xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/author | "Mack M."xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/author | "Peters A.M."xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/author | "Nice T.J."xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/author | "Robinson B.A."xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/author | "Van Winkle J.A."xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/author | "Nouboussi R.V."xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/name | "Cell Host Microbe"xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/pages | "665-676.e4"xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/title | "Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells."xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/30392829 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30392829 |
| http://purl.uniprot.org/citations/30392829 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30392829 |
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