| http://purl.uniprot.org/citations/30397075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30397075 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear factor kappa B (NF-κB) family of transcription factors plays a central role in coordinating the expression of genes that control inflammation, immune responses, cell proliferation, and a variety of other biological processes. In an attempt to identify novel regulators of this pathway, we performed whole-genome RNA interference (RNAi) screens in physiologically relevant human macrophages in response to lipopolysaccharide and tumor necrosis factor alpha (TNF-α). The top hit was SNW1, a splicing factor and transcriptional coactivator. SNW1 does not regulate the cytoplasmic components of the NF-κB pathway but complexes with the NF-κB heterodimer in the nucleus for transcriptional activation. We show that SNW1 detaches from its splicing complex (formed with SNRNP200 and SNRNP220) upon NF-κB activation and binds to NF-κB's transcriptional elongation partner p-TEFb. We also show that SNW1 is indispensable for the transcriptional elongation of NF-κB target genes such as the interleukin 8 (IL-8) and TNF genes. SNW1 is a unique protein previously shown to be involved in both splicing and transcription, and in this case, its role involves binding to the NF-κB-p-TEFb complex to facilitate transcriptional elongation of some NF-κB target genes."xsd:string |
| http://purl.uniprot.org/citations/30397075 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00415-18"xsd:string |
| http://purl.uniprot.org/citations/30397075 | http://purl.uniprot.org/core/author | "Verma I.M."xsd:string |
| http://purl.uniprot.org/citations/30397075 | http://purl.uniprot.org/core/author | "Verma S."xsd:string |
| http://purl.uniprot.org/citations/30397075 | http://purl.uniprot.org/core/author | "Chanda S.K."xsd:string |
| http://purl.uniprot.org/citations/30397075 | http://purl.uniprot.org/core/author | "De Jesus P."xsd:string |
| http://purl.uniprot.org/citations/30397075 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30397075 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/30397075 | http://purl.uniprot.org/core/pages | "e00415-18"xsd:string |
| http://purl.uniprot.org/citations/30397075 | http://purl.uniprot.org/core/title | "SNW1, a Novel Transcriptional Regulator of the NF-kappaB Pathway."xsd:string |
| http://purl.uniprot.org/citations/30397075 | http://purl.uniprot.org/core/volume | "39"xsd:string |
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