| http://purl.uniprot.org/citations/30397201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30397201 | http://www.w3.org/2000/01/rdf-schema#comment | "The interaction between natural killer (NK) cell inhibitory receptors and their cognate ligands constitutes a key mechanism by which healthy tissues are protected from NK cell-mediated lysis. However, self-ligand recognition remains poorly understood within the prototypical NKR-P1 receptor family. Here we report the structure of the inhibitory NKR-P1B receptor bound to its cognate host ligand, Clr-b. NKR-P1B and Clr-b interact via a head-to-head docking mode through an interface that includes a large array of polar interactions. NKR-P1B:Clr-b recognition is extremely sensitive to mutations at the heterodimeric interface, with most mutations severely impacting both Clr-b binding and NKR-P1B receptor function to implicate a low affinity interaction. Within the structure, two NKR-P1B:Clr-b complexes are cross-linked by a non-classic NKR-P1B homodimer, and the disruption of homodimer formation abrogates Clr-b recognition. These data provide an insight into a fundamental missing-self recognition system and suggest an avidity-based mechanism underpins NKR-P1B receptor function."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-06989-2"xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/author | "Fu Z."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/author | "Lanier L.L."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/author | "Berry R."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/author | "Carlyle J.R."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/author | "Gully B.S."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/author | "Aguilar O.A."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/author | "Balaji G.R."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/author | "Shingu-Vazquez M.A."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/pages | "4623"xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/title | "Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition."xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30397201 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30397201 |
| http://purl.uniprot.org/citations/30397201 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30397201 |
| http://purl.uniprot.org/uniprot/#_Q99JB4-mappedCitation-30397201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30397201 |
| http://purl.uniprot.org/uniprot/#_Q91V08-mappedCitation-30397201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30397201 |
| http://purl.uniprot.org/uniprot/Q99JB4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30397201 |
| http://purl.uniprot.org/uniprot/Q91V08 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30397201 |