| http://purl.uniprot.org/citations/30409537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30409537 | http://www.w3.org/2000/01/rdf-schema#comment | "There is an increasing interest in the putative role of glucagon-like peptide 1 receptor (GLP-1R) agonists as novel therapeutic agents for mental disorders. Herein, we investigated the expressions of GLP-1R and GLP-2R genes, and its relationship with body mass index (BMI), in the post-mortem brain tissue of patients with mood (MD) and psychotic disorders. Brain samples were localized to the dorsolateral prefrontal cortex (dlPFC) (n = 459) and hippocampus (n = 378). After adjustment for age, sex, ethnicity, post-mortem interval (PMI) and BMI, we observed significant differences, between healthy controls and MD subjects, in GLP-1R and GLP-2R gene expression in the dlPFC (β = 1.504, p = 0.004; and β = 1.305, p = 0.011, respectively); whereas in the hippocampus, only GLP-1R expression was significantly associated with MD (β = -1.28, p = 0.029). No significant differences were found in relation to schizophrenia. In addition, we observed a moderating effect of MD diagnosis on the associations between BMI, GLP-1R and GLP-2R expression values in the dlPFC (β = -0.05, p = 0.003; and β = -0.04, p = 0.004, respectively). There was a similar moderating effect for GLP-1R in the hippocampus (β = 0.043, 95% CI 0.003; 0.08 p = 0.03), but in an opposite direction than observed in the dlPFC. This is the first evidence of abnormal gene expression of GLP-1R and GLP-2R in postmortem brain of individuals with MD, providing a rationale for further inquiry and proof of principle interventional studies."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.euroneuro.2018.10.007"xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/author | "Lin K."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/author | "Ho R.C."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/author | "Lovshin J."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/author | "McIntyre R.S."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/author | "Fries G.R."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/author | "Vinberg M."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/author | "Brietzke E."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/author | "Mansur R.B."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/author | "Subramaniapillai M."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/author | "Trevizol A.P."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/name | "Eur Neuropsychopharmacol"xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/pages | "137-146"xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/title | "The effect of body mass index on glucagon-like peptide receptor gene expression in the post mortem brain from individuals with mood and psychotic disorders."xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/30409537 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30409537 |
| http://purl.uniprot.org/citations/30409537 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30409537 |
| http://purl.uniprot.org/uniprot/#_A0A142FHB8-mappedCitation-30409537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30409537 |
| http://purl.uniprot.org/uniprot/#_A0A384MTS7-mappedCitation-30409537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30409537 |
| http://purl.uniprot.org/uniprot/#_B4DIS8-mappedCitation-30409537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30409537 |
| http://purl.uniprot.org/uniprot/#_B2RAN4-mappedCitation-30409537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30409537 |
| http://purl.uniprot.org/uniprot/#_P43220-mappedCitation-30409537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30409537 |