| http://purl.uniprot.org/citations/30409884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30409884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30409884 | http://www.w3.org/2000/01/rdf-schema#comment | "During the process of cross-presentation, viral or tumor-derived antigens are presented to CD8+ T cells by Batf3-dependent CD8α+/XCR1+ classical dendritic cells (cDC1s). We designed a functional CRISPR screen for previously unknown regulators of cross-presentation, and identified the BEACH domain-containing protein WDFY4 as essential for cross-presentation of cell-associated antigens by cDC1s in mice. However, WDFY4 was not required for major histocompatibility complex class II presentation, nor for cross-presentation by monocyte-derived dendritic cells. In contrast to Batf3 -/- mice, Wdfy4 -/- mice displayed normal lymphoid and nonlymphoid cDC1 populations that produce interleukin-12 and protect against Toxoplasma gondii infection. However, similar to Batf3 -/- mice, Wdfy4 -/- mice failed to prime virus-specific CD8+ T cells in vivo or induce tumor rejection, revealing a critical role for cross-presentation in antiviral and antitumor immunity."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aat5030"xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aat5030"xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Virgin H.W."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Virgin H.W."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Beatty W.L."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Beatty W.L."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Lauron E.J."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Lauron E.J."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Sibley L.D."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Sibley L.D."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Mosammaparast N."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Mosammaparast N."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Desai P."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Desai P."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Diamond M.S."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Diamond M.S."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Brickner J.R."xsd:string |
| http://purl.uniprot.org/citations/30409884 | http://purl.uniprot.org/core/author | "Brickner J.R."xsd:string |