| http://purl.uniprot.org/citations/30413363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30413363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30413363 | http://www.w3.org/2000/01/rdf-schema#comment | "Lineage-committed αβ and γδ T cells are thought to originate from common intrathymic multipotent progenitors following instructive T cell receptor (TCR) signals. A subset of lymph node and mucosal Vγ2+ γδ T cells is programmed intrathymically to produce IL-17 (Tγδ17 cells), however the role of the γδTCR in development of these cells remains controversial. Here we generated reporter mice for the Tγδ17 lineage-defining transcription factor SOX13 and identified fetal-origin, intrathymic Sox13+ progenitors. In organ culture developmental assays, Tγδ17 cells derived primarily from Sox13+ progenitors, and not from other known lymphoid progenitors. Single cell transcriptome assays of the progenitors found in TCR-deficient mice demonstrated that Tγδ17 lineage programming was independent of γδTCR. Instead, generation of the lineage committed progenitors and Tγδ17 cells was controlled by TCF1 and SOX13. Thus, T lymphocyte lineage fate can be prewired cell-intrinsically and is not necessarily specified by clonal antigen receptor signals."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2018.09.010"xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2018.09.010"xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Kobayashi M."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Kobayashi M."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Kang J."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Kang J."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Yoshimoto M."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Yoshimoto M."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Kisielow J."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Kisielow J."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Jain N."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Jain N."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Narayan K."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Narayan K."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Spidale N.A."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Spidale N.A."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Melichar H.J."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Melichar H.J."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Serwold T."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Serwold T."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Frascoli M."xsd:string |
| http://purl.uniprot.org/citations/30413363 | http://purl.uniprot.org/core/author | "Frascoli M."xsd:string |